A novel therapeutic giving cancer patients new hope.

We are focused on rapidly advancing our lead therapeutic candidate, misetionamide (GP-2250), for the treatment of multiple cancer types including ovarian and pancreatic cancers.

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Our Science

Disrupting cancer cell metabolism.

Our unique and novel mechanism of action selectively disrupts the energy metabolism of cancer cells leading to cancer cell death as well as impacting nuclear factor-κB (“NFκB”) which effects cancer cells’ ability for protein synthesis and DNA transcription thereby restricting cancer cell growth and proliferation.

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Focused on Addressing Unmet Needs for Patients with Cancer.

Icon Pancreatic Cancer

Pancreatic
Cancer

Icon Ovarian Cancer

Ovarian
Cancer

Icon Additional Targets

Additional
Targets

Melanoma, Squamous Cell, Breast, Colorectal

Preclinical research with GP-2250 demonstrated significant anti-cancer activity in numerous established and primary cell lines. GP-2250’s novel MOA and degree of preclinical activity is exciting and could be a potentially important addition to the oncologists’ armamentarium to benefit patients.

Prof. Dr. med. Chris Braumann

EvK Gelsenkirchen, University of Duisburg-Essen, Germany

It is so refreshing to work with an organization that not only shares wholeheartedly in our mission to improve survival and quality of life for patients, but has truly unique science that provides new hope in the fight against cancer.

Dr. Anup Kasi, University of Kansas Medical Center

GP-2250 Phase 1 Principal Investigator

Truly novel.
Truly important.

We are on a mission to improve therapeutic outcomes for cancer patients with GP-2250, a tumor-cell selective agent with a truly novel mechanism of action.

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Focused on what matters most.

While GP-2250 has demonstrated broad utility across a number of indications and therapeutic uses in preclinical and Phase 1 clinical studies, including where inflammatory cytokine suppression could be of therapeutic value, we have chosen to focus on the treatment of pancreatic and ovarian cancers as our initial targets, two conditions with a clear unmet need. Early clinical experience is promising.   

Participate in our ongoing pancreatic cancer study

Early Clinical Results Improve Quality Of Life

The Latest

Press Release – October 9, 2024

Panavance Therapeutics Provides Update on Phase 1 Clinical Trial of Misetionamide in Pancreatic Cancer at 2024 Visceral Medicine Congress

Panavance Therapeutics Provides Update on Phase 1 Clinical Trial of Misetionamide in Pancreatic Cancer at 2024 Visceral Medicine Congress Misetionamide-gemcitabine combination demonstrates very good safety profile and potential therapeutic…
 
Press Release – August 14, 2024

Panavance Therapeutics Announces Foundational Publication of Misetionamide (GP-2250) in Ovarian Cancer in the Journal, Cancer Medicine

Panavance Therapeutics Announces Foundational Publication of Misetionamide (GP-2250) in Ovarian Cancer in the Journal, Cancer Medicine Misetionamide demonstrated significant single agent activity and synergy with either PARP inhibitors (PARPi)…
 
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Publication Summary – Misetionamide (GP-2250)

A summary of all publications with links to full document

 
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Mechanisms and rational combinations with GP-2250, novel oxathiazine derivative in ovarian cancer.

Mark Kim, Deanna Glassman, Katelyn F Handley, Adrian Lankenau ahumada, Emine Bayraktar, Nicholas B. Jennings, Robiya Joseph, Robert L. Coleman and Anil K. Sood.