About GP-2250

GP-2250 is a highly selective yet broadly active cancer therapeutic with a unique mechanism of action that suppresses cancers by disrupting their energy metabolism, bringing about cancer cell death.

Highly Selective Broadly Active Cancer Mechanism
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Differentiators

What Sets GP-2250 Apart?

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Broad oncology applications.

GP-2250 is a tumor-type agnostic agent that delivers broad utility across cancer etiologies.

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Robust data.

Early Phase 1 clinical data are encouraging and demonstrate excellent safety and tolerability of GP-2250, consistent with preclinical results.

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Cancer cell selective.

Because it targets the energy metabolism of cancer cells specifically, GP-2250 is highly tumor cell selective.

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Synergistic activity.

GP-2250 has demonstrated powerful synergies with several existing cancer treatments.

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Truly unique MOA.

GP-2250’s mechanism of action is patent-pending and based on truly novel science.

Interested in learning more?

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Mechanism of Action

Novel, patent-pending, transformative.

The real power of GP-2250 is its novel and patented mechanism of action, which targets two primary mechanisms of cancer cell energy production, causing metabolic and oxidative stress. Here’s how it works.

Normal cells and cancer cells generate energy differently. GP-2250 takes advantage of that difference.

GP-2250 decreases GAPDH, the enzyme that controls aerobic glycolysis, a key process in cancer cells’ ability to produce metabolic energy.

At the same time, GP-2250 also decreases αKGDH, an enzyme that is critical in the TCA cycle, a second process cancer cells rely on to create energy.

Together, the reduction of these two vital enzymes causes a significant decrease in ATP, the cell’s energy carrier, resulting in an oxidative and metabolic energy crisis.

AMPK is activated and the transcription factor NFkB is inhibited, generating metabolic stress. Meanwhile, reactive oxygen species (ROS) increases, generating oxidative stress. This results in apoptosis.

In addition, GP-2250’s reduction of NFkB results in anti-inflammatory, anti-angiogenic, and immuno-permissive activity.

 
 
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Watch Our Mechanism of Action Video.

Robust Multi Layer Protection

Intellectual Property

Robust, multi-layered protection.

  • Composition of Matter (NCE & Formulations) Granted US & EU (2033)
  • Manufacturing Process (2035-2036)
  • Method of Treatment (2037)
  • Mechanism of Action (2040-2041)
  • Next Generation Compounds (2042)

Pipeline

Broad applicability, intentional focus.

While GP-2250 has demonstrated broad utility across indications and therapeutic uses in preclinical and Phase 1 clinical studies, including where inflammatory cytokine suppression could be of therapeutic value, Panavance is focusing the initial clinical trials on pancreatic cancer—a condition with clear unmet needs. In addition, active preclinical studies focus on ovarian cancer.

Explore our Pipeline Diagram